- Recently, scientists conducted experiments on monoclonal antibody cocktail named REGEN-COV2.
- Antibody has been found to be life-saving treatment for severely affected Covid-19 patients.
- Monoclonal antibodies are artificial antibodies that perform the activity of our immune systems.
- They are produced by extracting specific antibodies from human blood and then cloning them.
- They are designed to target a virus or specific part of one the virus.
- For example, REGEN-COV2 is a cocktail of two monoclonal antibodies that targets SARS-CoV-2 spike protein.
- Monoclonal antibodies bind to specific parts of spike protein and block its ability to infect healthy cells.
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Uses of Monoclonal antibodies
- Monoclonal antibodies are used to treat cancers, Ebola and HIV, besides covid-19.
- Research, amid the covid-19 pandemic, are optimistic about abilities of monoclonal antibodies in reducing the risk of hospitalization.
- Monoclonal antibodies have also shown ability to retain activity against multiple variants of covid-19 virus.
Limitations of Monoclonal Antibodies
- Monoclonal therapies have shown results in high-risk groups with mild to moderate Covid-19 infections.
- However, they are not approved for use in severe Covid-19 cases that require oxygen.
- Further, emerging variants like Delta Plus have also displayed ability to nullify the use of monoclonal antibodies.